Background: COVID-19 pandemic shocked the world; it changes everybody's life, especially in education and online learning becomes a new culture. Aim of the study: To assess effect of online learning on psychological wellbeing, academic resilience, and self-efficacy among college students. Subjects and Methods: Research design: A descriptive design was employed. Setting: The study was conducted at faculty of nursing Benha University, Egypt. Subjects: A convenience sample of 400 students from the Faculty of Nursing at Benha University, Qalyubia Governorate. Tool of data collection: Tool (1) Personal data about the students. Tool (II) Psychological Well-being Scale. Tool (III) Academic Resilience Scale. Tool (IV). Online Learning Self-Efficacy Scale. Results: The findings revealed a negative impact of online learning on all three variables: Less than two-thirds of the students reported low levels of psychological well-being, suggesting potential detrimental effects on their mental and emotional health. Similar proportions of students exhibited low level of academic resilience and poor level of online learning self-efficacy, indicating decreased capacity to navigate academic difficulties with decrease student`s confidence in their ability to succeed in the online environment. Conclusion: Statistically significant strong correlations were observed on psychological wellbeing, academic resilience, and self-efficacy among college students. This suggests that lower academic resilience and online self-efficacy are associated with decreased psychological well-being. Recommendations: Develop and implement psycho-educational modules that enhance students' self-efficacy in online learning environments and Equip students with effective stress management skills and foster academic resilience to navigate challenges associated with online learning.