Background: Geriatric patients undergoing hemodialysis often grapple with persistent fatigue and poor sleep quality, which can significantly impact on their daily functioning and contribute to a diminished quality of life. Jacobson's progressive muscle relaxation, a structured technique involving the systematic tensing and subsequent relaxation of muscle groups alleviating theses hemodialysis consequences. Aim of the study was to evaluate the effect of Jacobson's progressive muscle relaxation on fatigue and sleep quality among geriatric patients undergoing hemodialysis. Subjects and Methods: Research design: A Quasi-experimental research design using one group pre-post 1and post2 test was used. Setting: The study was conducted in the dialysis units of Mansoura University Hospital and New Mansoura General Hospital. Subjects: A purposive sample of 61 geriatric patients who diagnosed with end-stage renal failure and on regular hemodialysis for at least 6 months. Tools of data collection: The data were collected through Mini– Mental State Examination, Structured interview schedule sheet, The Multidimensional Fatigue Inventory Scale and The Pittsburgh Sleep Quality Index. Results: The mean age of the studied geriatric patients was 67.869±4.863 years, a statistically significant change in fatigue level and sleep quality Index among the studied geriatric patients after application of Jacobson's progressive muscle relaxation (P=0.000**) was observed. Conclusion: implementation of Jacobson's progressive muscle relaxation evidenced to be effective in reducing the fatigue level and improving sleep quality among geriatric patients undergoing hemodialysis. Recommendation: For hemodialysis patients, practicing Jacobson's progressive muscle relaxation regularly is recommended to lessen fatigue and improve sleep quality.