Background: Chronic kidney disease (CKD) is a prevalent condition among elderly individuals, and it can significantly impact their quality of life. Health-promoting lifestyle practices can play a crucial role in managing CKD and improving the well-being of elderly patients. Aim of the study was to assess health promoting lifestyle practices among elderly patients with chronic kidney disease. Subjects and Methods: Research design:  A descriptive design was utilized. Setting: This study was conducted at inpatient renal ward in Internal Hospital at Zagazig University Hospital. Subjects: Purposive sample of 100 elderly patients with chronic kidney disease. Tool of data collection: Two tools was used Tool (I): A structured interview questionnaire sheet consisted of two parts; Part one: Demographic characteristics of the studied elderly patients, Part two: Health profile of the studied elderly patients. Tool (II): Health-Promoting Lifestyle Profile II.  Results of the current study revealed that (76% (of studied elderly patients not working, (80%) having insufficient income, (64%) of their income is son assistance and (37%) of the studied elderly were illiterate. Regarding medical profile of studied elderly, the result revealed that 68% of the studied elderly have family history of CKD and (67%) have any hemodialysis or peritoneal dialysis. 70% of studied patients had Moderate Level of health promotion lifestyle practices. Finally; there was statistically significant relations between health promotion lifestyle practices of studied patients and their age (p=0.005), their sex (p=0.019), their educational level(p=0.000) and their current work(p=0.047) and there were statistically significant relations between health promotion lifestyle practices of studied patients and their age(p=0.005), their sex(p=0.019), their educational level(p=0.000) and their current work(p=0.047).  Conclusion: that most of the studied elderly patients with chronic kidney disease had moderate level of health promoting lifestyle practices. Recommendations: Further studies to assess adherence to health promoting lifestyle practices of patients with chronic kidney disease.