Abstract Background: Ovarian cysts are a common finding in women of the reproductive age group. It is a common cause of gynecological surgery in all age groups. Adolescents have them frequently and harmlessly. Asymptomatic ovarian cysts are often identified during pelvic exams. Aim: To assess the effect of ovarian cysts on women quality of life. Subjects and Methods: Study Design: A descriptive study was used. Setting: Two settings; gynecology outpatient clinic and endoscopic unit at Zagazig university hospital. Study Subjects: A convenient sample of 200 women was included in the study. Tools of data collection: Two tools were used; structured interview questionnaire and questionnaire of the quality of life. Results: As for psychological health, the majority of women sometimes find it difficult to adapt to ovarian cyst. As for physical health, the majority of women sometimes was unable to travel and had less sexual desire. As for social health, the majority of them always reported that their relationship with family and friends were affected and they needed support from family and friends.  Conclusion: Ovarian cyst had a negative impact on woman's health-related quality of life; as more than half of women had average quality of life and more than one third of them had good quality of life, while it was poor in 3% of studied women. Recommendations: Women should be aware of the adverse impact of ovarian cyst on quality of life and health professionals should capture and consider perception of symptoms, the impact on quality of life and personal priorities for care to improve patient outcomes.