This paper proposes mechanical and growth characteristics of nature that inspire shapes to be applied to load-bearing walls. The problem is that this type of buildings needs a high cost due to its design without using optimization processes that have a big role in reducing cost while maintaining the required aesthetic shape. In this study, this is performed by analyzing the case studies of O-14 Building, Victoria Gate and The Broad Museum where the building materials used differ from case to case. A model was created through the SolidThinking Inspire program using the morphogenesis tool. The model design is based on the algorithm for topology optimization and will be compared in terms of structural and material performance with the selected case studies. Optimization results are found to be effective and designed with maximum stiffness in order to prevent deformation which is clearly reflected in the cost estimate in the initial design stages.