This study was conducted to investigate the antifungal effect of some Medicinal plants were garlic (raw, powder and oil) and clove (grain, powder and oil) and the drugs Nystatin, Clotrimazole and Fluconazole were used in this study. The tested fungi were (Saprolegnia spp. Cladosporium sp., Chrysosporium sp., Scopulariopsis brevicaulis, Aspergillus versicolor sp., Aspergillus ochraceus, Aspergillus niger, Aspergillus glaucus, Aspergillus wentii, Rhodotorulla sp., Penicillium sp., Syncephalastrum sp., Aspergillus tamarii., Aspergillus flavus, Trichoderma sp., Acremonium sp., Rhizopus sp., Fusarium sp., Phoma sp., Absidia sp., Aspergillus candidus, Alternaria sp., Aspergillus terreus, Aspergillus fumigatus and Paecilomyces sp.), which previously isolated from diseased fish. Raw Garlic was efficient against Absidia sp., while Garlic powder had positive effect against Aspergillus flavus, Aspergillus ochraceus, Fusarium sp., Rhizopus sp. and Absidia sp. Clove grain had postive effect against Fusarium sp., Rhizopus sp. and Absidia sp., on the other hand, clove powder affected in Fusarium sp., Rhizopus sp. and Absidia sp. Clotrimazole, Nystatin and Fluconazole, had positive effect against all tested fungi.