Introduction: The age- related to immune level decline affects many organs and organ systems which in turn has an effect on in components of blood cell {Hemoglobin, Wight Blood Cells, Red Blood Cells, Platelets, Lymphocyte, Monocytes& Neutrophil, as well as on cardio respiratory and musculoskeletal fitness. Evidence from longitudinal studies demonstrates that physical activity may attenuate this observed decline in fitness. The aim: of the current study was to study the effect of intervention resistance - Aerobic training (IRAT) 12 weeks, 3 times per week) on Changing immune-level and decreased risk of infection in elderly women. Methods: ten female subjects from police club aged 60-70 years were recruited through advertisements. They underwent an assessment of health state before testing and starting the exercise program controlled in the same training session for trained 3-month, three times a week, 60 min per session, on non-consecutive days and exercised under the supervision of a personal trainer, to determine changes in components of blood cell {Hemoglobin, Wight Blood Cells, Red Blood Cells, Platelets, Lymphocyte, Monocytes& Neutrophil} Result: Blood samples were obtained from all subjects {IRAT} pre at rest, post immediately after resistance exercise training, before start program and after week 12 after training. T-test for paired samples was performed to compare both time points (level of significance p<0.05). Conclusion:Increased components of blood cell and musculoskeletal after intervention between Resistance& Aerobic Training (IRAT) suggests that immunity has been improved