Background: Warts are considered as one of the most dermatological disease. Topical treatments such as hydrogen peroxide and potassium hydroxide could be a new agent with good safety and efficacy in treating viral warts, particularly those that do not respond to current treatments.
Aim of the work: This work aimed to compare between hydrogen peroxide and potassium hydroxide in treatment of viral wart.
Patients and Methods: The study was a comparative prospective analysis that was carried out on 100 patients complaining from viral wart, they divided into 2 groups, group [A]; include 50 patients treated with topical KOH 15% solution, and group [B]; include 50 patients treated with topical H₂O₂ 20% solution.
Results: Significant decrease in number of wart lesions after KOH 15 % solution application, and H₂O₂ 20 % solution application. Also, majority of patients [>80%] had moderate, marked, and excellent improvement. As well, most of patients were satisfied, with no significant difference between both groups. There was no any serious complications, however; few adverse effects as pain, Infection, Hyperpigmentation, and koebner phenomenon were presented in small number of patients, with no significant difference between both groups.
Conclusion: Topical KOH 15 % solution as well topical H₂O₂ 20 % solution are promising and efficient treatment for viral warts.