Background: Locally advanced breast cancer [LABC] defines the most advanced stage of non-metastatic breast cancer.  The neo-adjuvant chemotherapy [NACT] aims to permit removal of LABC by surgery. Breast conservative surgery describes the effective removal of the tumor with preservation of the breast appearance. However, in some cases, the achievement of both goals is difficult.
Aim of the work: This study designed to evaluate the results of the conservative breast surgery in cases of LABC following a favourable outcome from NACT.
Patients and Methods: This study was carried out in Surgical-Oncology Department, Sayed Galal Hospital and included females with LABC. All women were evaluated by history taking, clinical examination and radiological investigations. Then all were submitted to conservative breast surgery after assessment of neoadjuvant chemotherapy. The surgical and aesthetic outcomes were recorded and any complications were documented.
Results: The family history was positive for 20%. Most patients were on oral contraceptive pills and primipara. The most prevalent site was upper outer quadrant [UOQ] and 80% of patients showed partial response [PR], 16% showed complete response [CR] and 4% showed stationary disease [SD]. The outcome was excellent for 84% of the patients according to Cosmetic outcome distribution
Conclusion: Patients with LABC after NACT had great response with successful outcome from difference perspectives. Thus, neo-adjuvant chemotherapy followed by breast conservation surgery is a reasonable option for LABC treatment.