Background: The average age of first reproduction has increased dramatically throughout the world in recent decades. New evidence suggests that older parents have lower fertility and less healthy children. Most of these studies focused on men over the age of 60 who were infertile. Few studies have looked at how age affects normally fertile men under the age of 60.
Aim of the work: Assess the semenogram using Computer assisted semen analysis [CASA] and Hormonal studies that will include total and free testosterone, FSH, LH, Estrogen, prolactin and TSH in Egyptian men between age groups of 20 and 50 years in Damietta governorate, to assess if there is a decline in the overall parameters of sperm.
Patients and Methods: Two hundred adult males were recruited from the Dermatology outpatient clinic at the Damietta Campus of the Al-Azhar University School of Medicine for this cross-sectional study. All participants gave written consent and underwent a thorough history and physical examination, and their sperm was analyzed for a variety of parameters and their sexual hormone levels was measured after receiving approval from the local research committee.
Results: The semen volume, the total sperm count, sperm motility, progressive sperm motility and abnormal sperm morphology were statistically significantly lower in group C [40-49 years] compared to group A [20-29 years] and group B [30-39 years]. The FSH concentration and LH concentration was statistically significantly higher in group C [40-49 years] compared to group A [20-29 years] and group B [30-39 years].
Conclusion:  In healthy, fertile males, we found that as age increased, semen impairment also increased. The hormonal profile revealed changes that correlate with a reduction in the semen parameters, such as an increase in FSH, LH, Estradiol, and TSH levels.