Background: Whatever the cause or pathophysiology, middle ear inflammation is known as chronic suppurative otitis media [CSOM]. Because CSOM is resistant to local medicines, culture tests are regarded as the gold standard for identifying the causative agents.
The aim of the work: This study aims to detect microbiological profile [Bacteria and fungi] and antibiotic sensitivity pattern [For bacterial isolates] in CSOM.
Patients and Methods: This was a prospective study conducted on 100 patients with chronic suppurative otitis media who attended in the outpatient department at Al-Azhar university Hospitals from May 2022 to Feb 2023. Microbiological cultures and antibiotic susceptibility testing were performed on ear discharge samples collected from the study participants.
Results: The most predominant organism causing CSOM among aerobic bacteria was S. aureus, followed by Pseudomonas Aeruginosa, E. coli and Klebsiella Pneumoniae respectively. The fungal isolate was Candida species. Ciprofloxacin and Colistin were the best medications for treating Pseudomonas aeruginosa. Ciprofloxacin and Vancomycin were effective antibiotics for S. aureus. Amikacin and colistin were the most effective antibiotics for Klebsiella Pneumoniae. Colistin and Imipenem were the most effective antibiotics for E. coli.
Conclusion:  Understanding the microorganisms and drug sensitivity pattern that cause CSOM and selecting appropriate antibiotics based on susceptibility testing can direct the course of therapy and minimize intracranial and extracranial problems associated with the illness.