Background: For the management of extensive loss of hair, the follicular unit extraction technique [FUE] procedure for hair transplantation is a popular operative operation.
The Aim of the work: The goal of this investigation was to evaluate the morphological and histological changes in the transplanted hair follicles [HFs] after FUE for cases of androgenetic alopecia [AGA].  
Patients and Methods: It's a prospective interventional study that was carried out at Al Azhar University Hospitals between May 2018 and May 2023. In this investigation, 15 patients, ages 25 to 60, who were candidates for FUE hair transplantation and suffered from androgenetic alopecia were included. After 10–14 months following the procedure, the morphological and histological alterations in the transplanted FUs were contrasted with those of the native donor follicles.
Results: There was a substantial variation [p-value = 0.002] between the donor and recipient sites regarding sebaceous gland degeneration. The donor site in all studied patients [100%] had no Arrector pili muscle degeneration while at recipient site, there were 5 patients [33.3%] with no Arrector pili muscle degeneration, four patients [26.7%] with [+] Arrector pili muscle degeneration, four patients [26.7%] with [++] Arrector pili muscle degeneration and two patients [13.3%] with [+++] Arrector pili muscle degeneration. Regarding outer root sheath degeneration, this data demonstrates a very substantial variation [p-value < 0.001] between the donor and recipient sites. Regarding inner root sheath degeneration, this data demonstrates a very substantial variation [p-value < 0.001] between the donor and recipient sites.
Conclusion: The effect of the FUE procedure on the transplanted follicles is obvious morphologically and histologically, so it needs more interest, especially in the long run.