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339469

Diagnostic Significance of Serum Cystatin C as A Predictor of Severity in COVID-19 Infected Egyptian Patients

Article

Last updated: 24 Dec 2024

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Subjects

-

Tags

Internal Medicine

Abstract

Background: COVID-19 may produce a systemic inflammatory state and multiorgan dysfunction, including renal damage. Biochemical and radiological tests are important in assessing disease severity and selecting therapeutic options. Serum cystatin C [sCys C] is involved in immunomodulatory responses in inflammatory conditions and infections, and it reflects changes in borderline renal function.
The Aim of the work: Measurement of serum cystatin C levels in COVID-19 infected Egyptian participants as a predictor of the disease`s severity.  
Patients and Methods: This was an observational case-control study carried out on 80 participants, including 60 Egyptian COVID-19 patients and 20 healthy individuals as controls. All participants were investigated for laboratory, medical, and radiological features of COVID-19 as well as serum cystatin C. Patients were distributed into three categories according to illness severity; each group involved 20 patients: mild cases [group I], moderate cases [group II], and severe cases [group III].
Results: Serum cystatin C levels were found to be higher in group III patients, with a highly statistically significant difference between groups. Group III patients had higher levels of CRP, D-dimer, serum urea, and creatinine, with a highly statistically significant difference between groups. With a cutoff of >9.6, there was a significant link between serum systatin C and the severity of COVID-19 disease, with 96.8% sensitivity and 100% specificity.
Conclusion: The present study indicates that serum systatin C may serve as a tool for diagnosing potentially severe cases of COVID-19 infected Egyptian patients.

DOI

10.21608/ijma.2023.233684.1798

Keywords

COVID-19, Cystatin C, Acute phase response, Kidney Injury

Authors

First Name

Walaa

Last Name

Ashry

MiddleName

M. O.

Affiliation

Department of Medical Microbiology and Immunology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt

Email

walaaomar2011@gmail.com

City

Damietta

Orcid

0000-0003-1651-7453

First Name

Wafaa

Last Name

Elzefzafy

MiddleName

Mohammed

Affiliation

Department of Hepato-gastroenterology and Infectious Diseases, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt

Email

drwafaaelzefzafy@gmail.com

City

-

Orcid

-

First Name

Zakia

Last Name

Abouzahab

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt

Email

momima468@gmail.com

City

-

Orcid

-

First Name

Sabah

Last Name

Abd El Raheem

MiddleName

Ebrahem

Affiliation

Department of Clinical Pathology, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt

Email

ibrahim.mee801@gmail.com

City

-

Orcid

-

First Name

Eman

Last Name

Mohamed

MiddleName

El Sayed

Affiliation

Department of Clinical Pathology, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt

Email

emandalia2008@gmail.com

City

-

Orcid

-

First Name

Fatma

Last Name

Mohamed

MiddleName

Saffeyeldin

Affiliation

Department of Hepato-gastroenterology and Infectious Diseases, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt, Department of Internal Medicine, College of Medicine, Taif University, Taif, Saudi Arabia

Email

dr.eltonsy@gmail.com

City

-

Orcid

-

First Name

Awatif

Last Name

Edrees

MiddleName

Elmohamady

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt, Department of Internal Medicine, College of Medicine, Taif University, Taif, Saudi Arabia

Email

awatifedrees@gmail.com

City

-

Orcid

-

First Name

Mona

Last Name

Abdulwehab

MiddleName

Mohamed

Affiliation

Department of Clinical Pathology, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt

Email

monabdulwehab86@gmail.com

City

-

Orcid

-

Volume

5

Article Issue

12

Related Issue

45907

Issue Date

2023-12-01

Receive Date

2023-09-02

Publish Date

2023-12-01

Page Start

3,896

Page End

3,905

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 5_Issue 12_Pages 3896-3905.pdf

PDF . 1.0MB

Link

https://ijma.journals.ekb.eg/article_339469.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=339469

Order

339,469

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Diagnostic Significance of Serum Cystatin C as A Predictor of Severity in COVID-19 Infected Egyptian Patients

Details

Type

Article

Created At

24 Dec 2024