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318809

Role of Atropine in Attenuating the Side Effects of Propofol in Procedural Sedation in Anterior Shoulder Dislocation Reduction: A Randomized Controlled Trial

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Surgery

Abstract

Background: Propofol administration is associated with apnea, bradycardia, hypotension, and injection-site pain.
Aim of the work: To determine the impact of atropine in reducing the adverse effects of propofol used in procedural sedation for anterior shoulder dislocation [ASD] reduction.
Patients and Methods: This randomized, controlled, single-blind study was carried out on 50 patients aged from 18 to 60 years old, both sexes, undergoing ASD reduction. Patients were randomly assigned to two equal groups. Patients received 0.6 mg atropine in group 1 and saline in group 2 before propofol administration. Propofol 2 mg/kg and fentanyl 1 mcg/kg were utilized for sedation. Monitoring of heart rate [HR], and mean arterial pressure [MAP] were started just before the administration of atropine [T0] and at a one-minute interval after induction for 15 minutes [T1 -T15]. The incidence of apnea was recorded after propofol administration.
Results: The incidence of apnea was significantly lower with atropine compared to the control group [8% vs. 44%, P=0.004]. HR was significantly higher from T1 to T15 in group 1 compared to group 2 [P <0.05]. MAP was significantly higher from T5 to T15 group 1 than in group 2 [P <0.05]. Hypotension [MAP<65mmHg] and bradycardia [HR<60 beats/min] were insignificantly different between both groups. Allergies did not occur in both groups.
Conclusion: In ASD reduction, atropine attenuates the negative effects of propofol by reducing the incidence of apnea and avoiding the decrease in HR and MAP.

DOI

10.21608/ijma.2023.226369.1751

Keywords

propofol, atropine, Sedation, Apnea, anterior shoulder dislocation

Authors

First Name

Wafaa

Last Name

Abdelsalam

MiddleName

-

Affiliation

Department of Anesthesia and Postsurgical Intensive Care Unit, Faculty of Medicine, Kafrelshiekh University, Kafrelshiekh, Egypt

Email

wafaa_abdelbaky2015@med.kfs.edu.eg

City

Kafrelshiekh

Orcid

-

First Name

Mohamed

Last Name

Elbahnasawy

MiddleName

-

Affiliation

Department of Emergency Medicine and Traumatology, Faculty of Medicine, Tanta University, Tanta, Egypt

Email

mohamed.elbahnaswy@med.tanta.edu.eg

City

Tanta

Orcid

-

First Name

Basma

Last Name

Ghoniem

MiddleName

M.

Affiliation

Department of Anesthesia and Postsurgical Intensive Care Unit, Faculty of Medicine, Kafrelshiekh University, Kafrelshiekh, Egypt

Email

drbasmaghoniem@gmail.com

City

Kafr elshekh

Orcid

-

First Name

Mahmoud

Last Name

Elsharkawy

MiddleName

Fawzy

Affiliation

Department of Anesthesia and Postsurgical Intensive Care Unit, Faculty of Medicine, Kafrelshiekh University, Kafrelshiekh, Egypt

Email

mahmoud83me@gmail.com

City

Kafrelshiekh

Orcid

-

First Name

Gamal

Last Name

Shams

MiddleName

Hendawy

Affiliation

Department of Anesthesia and Postsurgical Intensive Care Unit, Faculty of Medicine, Kafrelshiekh University, Kafrelshiekh, Egypt

Email

gamal.shams2@gmail.com

City

Kafr Elsheikh

Orcid

-

Volume

5

Article Issue

8

Related Issue

43785

Issue Date

2023-08-01

Receive Date

2023-07-31

Publish Date

2023-08-01

Page Start

3,554

Page End

3,560

Print ISSN

2636-4174

Online ISSN

2682-3780

Link

https://ijma.journals.ekb.eg/article_318809.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=318809

Order

10

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Role of Atropine in Attenuating the Side Effects of Propofol in Procedural Sedation in Anterior Shoulder Dislocation Reduction: A Randomized Controlled Trial

Details

Type

Article

Created At

24 Dec 2024