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303540

Assessment of Autotaxin, Oxidized LDL and β2-Microglobulin in Patients with Diabetic Nephropathy

Article

Last updated: 24 Dec 2024

Subjects

-

Tags

Basic Sciences

Abstract

Background: Diabetes mellitus [DM] is a metabolic condition characterized by hyperglycemia caused by deficiencies in insulin action or secretion or both. Diabetes' persistent hyperglycemia is linked to long-term organ failure, including kidney loss of functions, leading to diabetic nephropathy [DN].
Aim of the work: This study aims to assess the value of serum autotaxin [ATX], oxidized LDL [ox LDL], and β2-microglobulin [β2M] as biomarkers for DN patients.
Patients and Methods: This cross-sectional study included 100 subjects divided into three groups. Group 1; control group [20 healthy subjects]. Patients were subdivided into two groups, group 2 [40 patients diagnosed with DN stages Ⅰ, Ⅱ, and Ⅲ], and group 3 which involved 40 patients diagnosed with DN stages Ⅳ and Ⅴ.
Results: As regards the ATX, it was significantly higher in group 3 than in group 1 and group 2 with a statistically significant difference between every 2 groups [P value > 0.05 for all]. In terms of Ox LDL and β2M, the difference between the three groups was significant statistically [P value = 0.005, and 0.002 respectively], however the difference between group 2 and group 3 was not significant [P value = 0.44, and 0.98 respectively].
Conclusion: Serum autotaxin, ox LDL, and β2M can be used as diagnostic noninvasive biomarkers in DN.

DOI

10.21608/ijma.2023.185294.1590

Keywords

autotaxin, Oxidized LDL, Β2-Microglobulin, diabetic nephropathy

Authors

First Name

Mahmoud

Last Name

Farid

MiddleName

-

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Email

mahmoudfarid2014a@gmail.com

City

-

Orcid

-

First Name

Sayed

Last Name

Mahmoud

MiddleName

A. M.

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Email

sayedayoub@gmail.com

City

-

Orcid

-

First Name

Moussa

Last Name

Madanay

MiddleName

Moustafa

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Email

mousamadany@gmail.com

City

-

Orcid

-

First Name

Mohammed

Last Name

Bakeer

MiddleName

Said

Affiliation

Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Email

mohamedbakir@yahoo.com

City

-

Orcid

-

Volume

5

Article Issue

4

Related Issue

41899

Issue Date

2023-04-01

Receive Date

2023-05-05

Publish Date

2023-04-01

Page Start

3,191

Page End

3,196

Print ISSN

2636-4174

Online ISSN

2682-3780

Link

https://ijma.journals.ekb.eg/article_303540.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=303540

Order

6

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Assessment of Autotaxin, Oxidized LDL and β2-Microglobulin in Patients with Diabetic Nephropathy

Details

Type

Article

Created At

24 Dec 2024