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297279

Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study]

Article

Last updated: 04 Jan 2025

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-

Tags

Basic Sciences

Abstract

Background: Several industrial products [such as paints, cosmetics, and petrol] contained metals like lead [Pb], which are harmful to people. The reproductive organs are the primary organs affected by heavy metal toxicity through the production of oxidative stress. Selenium and curcumin could help to counteract this toxicity.
Aim of the work: We investigated the possible role of Selenium or curcumin in improving the testicular toxicity caused by the intake of Lead orally in albino rats.
Materials and Methods: 40 adult male albino rats were selected and unsystematically separated into 4 groups [10 rats/each] included: Group 1: control group; Group 2: Pb-exposed group; Group 3: Pb plus Selenium and Group 4: Pb plus Curcumin. Blood samples were collected for examination of serum biochemical parameters, serum Testosterone, LH, FSH levels, Total Anti-oxidant Capacity [TAC], testicular tissue oxidative stress parameters and testicular histology were evaluated.
Results: Oral administration of Pb to rats for 4 weeks disturbs the testicular structure and function with a significant increase in the oxidative stress enzymes, deposition of collagen fibers and anticaspase-3 in the testis. While, administration of either Selenium or Curcumin with Pb-exposure induced significant improvement of all the testicular changes.
Conclusion: Chronic lead exposure causes deteriorating changes in the testicular structures and functions which could be improved by oral intake of either Selenium or Curcumin by their antioxidant, antifibrotic, and antiapoptotic properties.

DOI

10.21608/ijma.2023.203141.1659

Keywords

Lead, testis, Oxidative Stress, selenium, Curcumin

Authors

First Name

Alsayed

Last Name

Abdel Hady

MiddleName

A.

Affiliation

Department of Anatomy, Faculty of Medicine, Helwan University, Helwan, Egypt.

Email

abdrahmankellany@yahoo.com

City

-

Orcid

-

First Name

Ezz-Eldin

Last Name

Abd-Allah

MiddleName

E.

Affiliation

Department of Histology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt

Email

ezz_75@hotmail.com

City

-

Orcid

-

First Name

Nahed

Last Name

Emam

MiddleName

M. M.

Affiliation

Department of Zoology, Faculty of Science, Al Arish University, North Sinai, Egypt

Email

nahedemam2018@yahoo.com

City

-

Orcid

-

First Name

Alaa Eldein

Last Name

El-Sagheer

MiddleName

Sayed

Affiliation

Department of Anatomy, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Email

alaasemary2013@yahoo.com

City

-

Orcid

-

First Name

Amr

Last Name

Younes

MiddleName

M.

Affiliation

Department of Anatomy and Embryology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt

Email

dr.amryounis87@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdel Monsef

MiddleName

S.

Affiliation

Department of Physiology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.

Email

dr.physiologist.as@gmail.com

City

-

Orcid

-

First Name

Amany

Last Name

Wahb

MiddleName

M.

Affiliation

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Helwan University, Helwan, Egypt

Email

amany.wahb@med.helwan.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Moustafa

MiddleName

E.

Affiliation

Department of Medical Biochemistry, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.

Email

elhoshyaso@yahoo.com

City

-

Orcid

-

First Name

Mokhtar

Last Name

Abo-Elfotoh

MiddleName

A. Mokhtar

Affiliation

Department of Forensic Medicine and Clinical Toxicology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt

Email

mokho802003@gmail.com

City

Mansoura

Orcid

-

First Name

E.

Last Name

Tayee

MiddleName

M.

Affiliation

Department of Clinical Pharmacology, Faculty of Medicine, Helwan University, Helwan, Egypt.

Email

dr_sayed_1978@yahoo.com

City

-

Orcid

-

First Name

Noha

Last Name

Shawky

MiddleName

O.

Affiliation

Department of Medical Physiology, Faculty of Medicine, Helwan University, Helwan, Egypt

Email

noha.osama@med.helwan.edu.eg

City

-

Orcid

-

Volume

5

Article Issue

2

Related Issue

41128

Issue Date

2023-02-01

Receive Date

2023-03-30

Publish Date

2023-02-01

Page Start

3,045

Page End

3,053

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 5_Issue 2_Pages 3045-3053.pdf

PDF . 1.8MB

Link

https://ijma.journals.ekb.eg/article_297279.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=297279

Order

6

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Protective Effects of Curcumin and Selenium on Testicular Toxicity Induced by Lead Acetate in Adult Male Albino Rats [Structural and Biochemical Study]

Details

Type

Article

Created At

24 Dec 2024