Background: Despite laparoscopic cholecystectomy being less invasive, patients report significant pain within the first 24 h following surgery. To minimize post-operative pain, a number of preoperative, intraoperative, and postoperative pain management techniques are available. These include low-pressure pneumoperitoneum, use of opioids, local anesthetic infiltration, intraperitoneal instillation, thoracic paravertebral or epidural blocks, and intraperitoneal infiltration of local anesthesia. 
Aim of the work: This research aimed to evaluate rectus sheath block versus local infiltration with regard to efficacy at the port sites with an intraperitoneal injection of bupivacaine for pain control following a laparoscopic cholecystectomy.
Patients and Methods: This prospective comparison research involved 80 patients including both genders who were set for laparoscopic cholecystectomy. Two groups of patients were determined: Group I: Received 30 ml of 0.25 % bupivacaine 15 ml for intraperitoneal instillation and 15 ml for local infiltration at the port sites. Group R: Bupivacaine 0.25% in 30 ml was administered bilaterally [RSB] [15 ml on each side].
Results: Regarding postoperative [VAS], there was statistically significant variation among the two groups at 16 and 24 hours postoperatively [p= 0.013]. As for postoperative request analgesia, the intraperitoneal instillation group [11.8 ± 0.34 hour] and the RSB group [17.16 ±4.83 hour] as needed their first dose of rescue analgesic. Statistical analysis revealed clear group distinction [p = 0.002]. Regarding patient satisfaction. No significant variations were observed between the groups.
Conclusion: Bupivacaine intraperitoneal infused with local infiltration at the port sites an effective analgesic approach, as is ultrasound-guided rectus sheath block, but [RSB] was better due to longer postoperative pain relief and less opioid consumption. Both methods are easy, risk-free, and without adverse effects.