Beta
ManageSearchChatDiscover
292146

Impact of Antioxidants on Pancreatic B-Cell Damage Caused by Streptozotocin in Adult Male Albino Rats

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Basic Sciences

Abstract

Aim of the Work: To evaluate the effect of streptozotocin on the endocrinal functions of the pancreatic gland, and the potential protective effects of vitamin-E in adult male albino rats.
Materials and Methods: The Al-Azhar University of Medicine in Cairo's animal house, where this investigation was carried out, between March and May 2022. 50 adult male albino rats were randomly assigned to one of five equal groups: normal control group I, olive oil-treated control group II, vitamin-E-treated control group III, and streptozotocin-treated control group IV and streptozotocin-vitamin E-treated group V.
Results: Streptozotocin-treated group [group IV] was connected to significantly higher serum glucose levels, Malondialdehyde [MDA], interleukin-1b, and interleukin-6 levels and decreased level of serum insulin and glutathione [GSH] in comparison to the normal control groups. This was supported by the islets of Langerhans exhibiting areas of necrosis, vacuolation, and deformation of the pancreatic tissue's typical architecture. Lipid peroxidation was significantly reduced in the group that received vitamin E and streptozotocin. [group V] represented by a significant decrease of serum glucose, MDA, interleukin-1b, and interleukin-6 levels. Histopathological changes were improved after receiving vitamin E.
Conclusion: In adult male albino rats, streptozotocin-induced changes to the pancreas might be prevented by vitamin E.

DOI

10.21608/ijma.2023.194972.1630

Keywords

streptozotocin, Vitamin- E, Insulin, pancreas, diabetes

Authors

First Name

Nageh

Last Name

Gabr

MiddleName

Mabrouk

Affiliation

Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

drmedicinephys@yahoo.com

City

-

Orcid

-

First Name

Fayez

Last Name

Elbayoumy

MiddleName

Mohammed Abd Elfattah

Affiliation

Department of Anatomy and Embryology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

fayez@yahoo.com

City

-

Orcid

-

First Name

Alaa El Dein

Last Name

Omar

MiddleName

Sayed El Sagheer

Affiliation

Department of Anatomy and Embryology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

alaaeldein@gmail.com

City

-

Orcid

-

First Name

Abd El-Lateef

Last Name

Abd El-Lateef

MiddleName

Saeed

Affiliation

Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

abdel-lateef@yahoo.com

City

-

Orcid

-

First Name

Alaaeldin

Last Name

Eissa

MiddleName

Ahmed Mohamed Ali

Affiliation

Department of Pharmacology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.

Email

alaaeldin@gmail.com

City

-

Orcid

-

First Name

Amr

Last Name

Younes

MiddleName

Mohamed

Affiliation

Department of Anatomy and Embryology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.

Email

amr1554@yahoo.com

City

-

Orcid

-

First Name

Khaled

Last Name

Elhamaky

MiddleName

Saleh Ali

Affiliation

Department of Medical Physiology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.

Email

khaled12@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Abbas

MiddleName

Ali Mahmoud

Affiliation

Department of Medical Physiology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.

Email

drmohamedali122@gmail.com

City

New-Damietta

Orcid

-

Volume

5

Article Issue

1

Related Issue

40592

Issue Date

2023-01-01

Receive Date

2023-02-20

Publish Date

2023-01-01

Page Start

2,944

Page End

2,950

Print ISSN

2636-4174

Online ISSN

2682-3780

Article File

IJMA_Volume 5_Issue 1_Pages 2944-2950.pdf

PDF . 1.2MB

Link

https://ijma.journals.ekb.eg/article_292146.html

Detail API

https://ijma.journals.ekb.eg/service?article_code=292146

Order

3

Type

Original Article

Type Code

816

Publication Type

Journal

Publication Title

International Journal of Medical Arts

Publication Link

https://ijma.journals.ekb.eg/

MainTitle

Impact of Antioxidants on Pancreatic B-Cell Damage Caused by Streptozotocin in Adult Male Albino Rats

Details

Type

Article

Created At

24 Dec 2024