Background: Patients with diabetes foot wounds had a 2.5-fold higher risk of passing away than diabetic patients without foot wounds did. the development of a diabetic foot wounds is associated with a 5% mortality in the first 12 months and a 42% mortality within 5 years.
Aim of the work: The purpose of our study was to evaluate the combination of vacuum assisted closure therapy and platelet rich plasma for management of diabetic foot wound.  
Patients and methods: This prospective study was conducted at New Damietta University Hospital and National Institute of Diabetic and Endocrinology at Cairo. This study was conducted on 30 patients diagnosed as diabetic foot wound and aim to evaluate the combination of Vacuum assisted closure therapy for two sections par week for two weeks and many patients need three weeks for complete granulation phase and Platelet Rich Plasma injected into wound two sections par week for two weeks for epithelization the wound.
Results: Regarding size, depth and discharge of wound on VAC size at baseline was 106.58 cm², depth of 10.7 mm and no discharge was observed. After 7 days, size was 100.58, depth was 7.03 mm and discharge were 172. In day 14, size decreased to 91.52 cm², depth was 3.87 mm and discharge reached 128.67. At day 21 Size was 92.57 cm², depth was 2 mm and discharge were 80.
Conclusion: Negative pressure wound therapy is a promising technique gaining rapid popularity in DFU management all over the world. Faster wound healing and shorter hospital stays are observed, with few or no problems. Consequently, it is effective in treating diabetic foot ulcers. PRP therapy is a method for increase the epithelized area of Diabetic Foot Ulcers faster and comfortable for patient compered to standard treatment in this time.