Background: Worldwide, diabetes mellitus [DM] continues to be a major source of morbidity and mortality and is a critical public health issue. Diabetic foot ulcers are significant sources of distress and discomfort for many diabetic patients, with frequent resistance to treatment.
Aim of the work: This study's objective was to assess the frequency of microbes that cause diabetic foot ulcers, in order to reduce morbidities associated with this condition.   
Patients and methods: One hundred diabetic patients with infected foot ulcers who were undergoing surgery in the outpatient clinic at Al-Azhar University Hospital in New Damietta were included in this study. Samples were obtained from each patient for microbiological testing and antibiotic sensitivity.
Results: The most found organism was staphylococcus aureus [19%] among gram-positive and E. coli [13%] among gram-negative, and longer diabetes duration and T1DM were significant risk factors for microbial growth.
Conclusion: From the results of the study we can conclude that the most found organism was staphylococcus aureus among gram-positive and E. coli among gram-negative. Longer diabetes duration and T1DM were significant risk factors for microbial growth.