In Egypt, there were many earthquakes activities in seismo-tectonic regions. In the last century most of earthquakes concentrated at Gulf of Suez and Gulf of Aqqaba. Also, Egypt affected by large earthquakes in the northern Mediterranean Sea. In this study, we are trying to evaluate the crustal displacement associated with the large earthquakes activities by using of GNSS measurements. GNSS observations can measure the horizontal and vertical displacement within mm of accuracy. Earthquakes with magnitude more than 4 have been chosen. The crustal displacements have been computed using GNSS data from Egyptian Permanent Geodetic Network (EPGN). The results show that before and during and after earthquakes activities, the displacement of GNSS stations gives different behavior depending on its distance from earthquakes epicenter. In some studied GNSS station, there was a signal of deformation before the earthquake found. This displacement can used in establishment of early warning system for earthquakes using GNSS observations.