The present experiment was executed to detect the extent to which growth performance and some related blood metabolic parameters are influenced by different levels of energy and protein in Hubbard efficiency plus chicks. A total 234 one day old chicks. Chicks were divided to 6 groups: 39 chicks in each. GroupI received a basal diet containing standard energy and protein. GroupII, received a diet containing standard protein and 10%low energy GroupIII, received a diet containing standard protein and 20%low energy. GroupIV, received a diet containing standard energy and 10%low protein. GroupV, received a diet containing standard energy and 20%low protein and GroupVI, received a diet containing 20%low energy-10%low protein. During the experiment that lasted 6 weeks, body weight, weight gain, feed intake and FCR were recorded weekly. Serum glucose, Insulin and corticosterone level were also measured. The results demonstrated that body weight of all groups showed marked decrease compared to control group except 10%LP group showed an unremarkable decrease in week 3 of age. In week 5 and week 6, 20%LE-10%LP group and 20%LE group displayed the highest feed intake compared to control. Also, FCR, during whole experimental period, 20%LE-10%LP group and 20%LE group recorded pronounced increase in FCR compared to control. serum level of glucose and insulin revealed significant(P>0.05) decrease. Whereas serum level of corticosterone displayed significant(P> 0.05) increase in 20% LE and 20%LE-10%LP group compared to control group. In conclusion, low energy had marked effect on growth performance and related metabolic blood hormones than low protein.