Canine parvoviral enteritis (CPVE) is a global contagious disease of dogs caused by three variants of canine parvovirus type 2 (CPV2). This present study aims to assess the values of hematological parameters and oxidative stress as confirmation markers for CPV2 infection in household dogs. A total of ten suspected diseased dogs (less than 6 months) by Parvo virus were introduced to the Awsim veterinary hospital at Giza governorate. Dogs were diagnosed primarily according to clinical signs (fever, bloody diarrhea, vomiting, depression, and anorexia) and fecal SNAP test (Ag test kits for parvo). The result of SNAP test revealed that five dogs were negative, and five dogs were positive for CPV2 which was further examined by hematology and oxidative markers. Hematological examination in CPV2 infected dogs showed macrocytic hypochromic non-regenerative anemia, leukocytosis, and thrombocytopenia. The differential leucocytic count revealed relative lymphocytosis and monocytosis with non-significant change in eosinophil and basophil count in CPV2 infected compared to apparently healthy control dogs. On the other hand, oxidative stress assessment revealed decline in the mean values of MDA, GPx, CAT and increase in level of SOD in CPV2 infected dogs compared to apparently healthy control. These findings shed light on the potential diagnostic utility of hematological parameters and oxidative stress markers in confirmation CPV2 infection in household dogs.