The purpose of this study was to measure the antioxidant state and reactive oxidative stress in the HPG2 cell line in order to explore the effects of Taxol, Atorvastatin, and proanthocynadin. In this study, the effects of Atorvastatin, a novel 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and Proanthocynadine, the most prevalent polyphenol class in the human diet, on a range of metabolic diseases and chemotherapeutic effects were investigated, Taxol, a chemothrbutic drug is substance derived from the bark and trunk of the Yew Pacific tree, was shown to assist induce and enhance tubulin polymerization and assembly while also preventing its depolymerization effects on oxidative stress and antioxidant enzymes. Taxol, Atorvastatin, and Proanthcyanidine inhibited the viability of HepG2 cells in a time- and dose-dependent manner, and induced a significant increase in antioxidant enzyme concentrations of superoxide dismutase (SOD), catalase, glutathione reductase, and malondialdehyde (MDA) in all treated groups compared to untreated cells.