Cisplatin is an anticancer drug with high efficiency against various types of tumors including head and neck, bladder, ovarian, lung, and testicular cancers. However, its use is limited due to its toxicity to various tissues including hepatotoxicity. Seven groups (n=10) of rats were used. Group I received normal saline, group II received garlic (200 mg /kg) and group III received ginger (310 mg/kg body weight) orally, once per day for consecutive 21 days. Group IV received saline + cisplatin on 16th day [10 mg/kg, intraperitoneal (IP)]. Group V received garlic + cisplatin on 16th day. Group VI received ginger + cisplatin on 16th day and group VII received garlic and ginger + cisplatin on 16th day. Cisplatin induced a significant (P<0.05) increase in hepatic serum biomarkers including AST, ALT and ALP levels and a significant (P<0.05) decrease in ALB level. Moreover, cisplatin induced a significant (P<0.05) increase in MDA level and caused a significant (P<0.05) depletion in CAT, GSH and SOD levels in liver tissues. Furthermore, cisplatin induced severe histopathological alteration in liver tissue. Garlic and ginger have hepatoprotective and antioxidant activities, which may be beneficial for protecting against liver damage.