Mycoplasma bovis-related diseases in cattle are a global issue that negatively affects 
cattle husbandry in terms of both animal welfare and the economy. Many clinical 
symptoms, such as mastitis, pneumonia, infertility and abortion, otitis media, 
keratoconjunctivitis, and arthritis. To find gaps in our understanding of the causative 
organism regarding disease pathology, diagnosis, and control techniques, we examine 
and analyze the available data on diagnosis and control. The following are the main 
factors to consider there are no commercially available vaccines; antimicrobial 
resistance is rising; diagnostic and antimicrobial sensitivity testing need to be 
improved; and a pen-side test would enable quicker diagnosis and antimicrobial 
treatment implementation. It is necessary to gather more information on immune 
response, stress variables, infectious dosage levels, and host susceptibility. Further 
research is required to understand the effects of a symptomatic carriers, on the survival 
of M. bovis in the environment. In order to accelerate the development of vaccines, 
additional genomic study of M. bovis is necessary, its pathogenic mechanisms, which 
include variable surface proteins, and repeatable disease models.