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352697

Applications of Bioinformatics on Genomics and Proteomics Levels Highlighted in Brucella Pathogen

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Internal medicine & Infectious disease

Abstract

In a variety of industries, including biotechnology and medicine, bioinformatics is
extremely important. It offers an extensive range of uses in the structural and
sequencing analysis of biological data. Each application has distinct functions in data
interpretation, as database search sequence and alignment are essential tools that are
prerequisites for more advanced applications like modelling, epitope predictions, and
molecular docking. Genome annotation is thought to be the key to decoding the
meaningless sequence data and providing crucial details about the protein-coding genes
and genomic characteristics. Additionally, comparative modelling, fold modelling, and
ab initio modelling are the three main approaches to protein modelling, which is
fundamental for various proteomics applications. Epitopes prediction for B cells and T
cells using MHC I and MHCII is another significant use. This may aid in the development
of novel vaccine candidates for the prevention and management of infectious illnesses.
Software can virtually dock the created 3D model or predicted epitopes with ligand to
construct a new medicine or vaccination quickly and affordably. Using bioinformatics
tools in diagnosis and control of brucellosis has a promising vision to eliminate the
disease. 

DOI

10.21608/jcvr.2024.352697

Keywords

Brucellosis, Comparative analysis, Epitopes Prediction, Molecular docking, Protein Modelling

Authors

First Name

Alyaa

Last Name

Elrashedy

MiddleName

-

Affiliation

-

Email

alyaaelrshedy96@gmail.com

City

-

Orcid

0000-0002-6746-9888

First Name

Mohamed

Last Name

Nayel

MiddleName

-

Affiliation

-

Email

mohamedaboalez@yahoo.com

City

-

Orcid

0000-0001-9048-0746

First Name

Akram

Last Name

Salama

MiddleName

-

Affiliation

-

Email

akram.salama@vet.usc.edu.eg

City

-

Orcid

0000-0002-8047-8965

First Name

Mohamed

Last Name

Hasan

MiddleName

E.

Affiliation

-

Email

mohamed.elsaid@gebri.usc.edu.eg

City

-

Orcid

-

Volume

6

Article Issue

1

Related Issue

47428

Issue Date

2024-04-01

Receive Date

2024-04-30

Publish Date

2024-04-01

Page Start

1

Page End

15

Print ISSN

2636-4018

Online ISSN

2636-4026

Link

https://jcvr.journals.ekb.eg/article_352697.html

Detail API

https://jcvr.journals.ekb.eg/service?article_code=352697

Order

352,697

Type

Original Article

Type Code

799

Publication Type

Journal

Publication Title

Journal of Current Veterinary Research

Publication Link

https://jcvr.journals.ekb.eg/

MainTitle

Applications of Bioinformatics on Genomics and Proteomics Levels Highlighted in Brucella Pathogen

Details

Type

Article

Created At

24 Dec 2024