Background: Thyroid nodule(s) is the second most common endocrine disorder after diabetes. They are more common in females (4:1-F:M) and have an increasing prevalence with increasing age and reduced iodine intake. This study aimed to evaluate the efficacy and safety of ultrasound-guided radiofrequency ablation (RFA) for treatment of benign thyroid nodules as well as preservation of the normal thyroid function. Methods: This prospective study included 30 patients with pathologically proved benign thyroid nodules. Patients included in the study were (5 males and 25 females) ranging in age between 21 and 60 years with a mean age of 32.5 years. Results: There was significant volume reduction of the ablated thyroid nodules by 68.6% at 3-month follow up (P value = 0.0001). Also, the compressive symptoms score and cosmetic scale improved significantly after RFA (P value = 0.0001). Conclusion: RFA was effective in reducing the size of the benign thyroid nodules and in controlling nodule-related compressive symptoms as well as cosmetic problems. RF ablation can be used as an alternative non-surgical minimally invasive treatment for patients with benign thyroid nodules.