Background: Multiple Sclerosis (MS) is a chronic immune-mediated degenerative disease of the central nervous system (CNS) characterized by localized areas of inflammation, demyelination, axonal loss and glial scar formation (sclerosis) in the brain and spinal cord. This study aimed to evaluate the role of advanced MRI techniques in assessment of multiple sclerosis disease of the brain. Methods: This prospective study included 100 patients with Multiple sclerosis. All studied cases were subjected to general and neurological examination of the patients. Conventional MRI including [Axial T1WI, T2WI, FLAIR, Sagittal FLAIR]. Non- conventional MRI modalities [MRS, MTI, MTR, DTI, SWI]. Results: The mean CNR for Cube FLAIR is significantly greater than that for FLAIR T2, and the statistical test result confirms this with a highly significant p-value (