Background: Chronic endometritis (CE) reflects a chronic inflammatory state within endometrium. This study aimed to investigate the value of hysteroscope in diagnosing chronic endometritis and also evaluate the prevalence of chronic endometritis in patients with recurrent implantation failure and recurrent pregnancy loss by hysteroscope and biopsy. Methods: This is a prospective interventional study that was performed at Benha University Hospital and a private gynecology center during the period from June 2022 and December 2022. The study included 20 women undergoing hysteroscope indicated by common conditions such as chronic pelvic pain, recurrent implantation failure, and recurrent miscarriage during the study period. The study patients underwent office hysteroscope examination and histopathological examination. Results: There were statistically significant differences between patients with chronic endometritis and those without in the presence of diffuse endometrial hyperemia (p=0.005) and dilated vessels (p=0.035), with statistically higher scores in the group of chronic endometritis (p=0.002). The ROC revealed that a score cutoff value of > 2 was able to diagnose chronic endometritis with an excellent performance (AUC=0.923). It showed a sensitivity of 87.5% and a specificity of 85.7% (p=0.002). There was substantial agreement between the hysteroscopic diagnosis by the new scoring system and the histopathological diagnosis (kappa=0.792 and p=0.002). Conclusion: From the study findings, hysteroscopy is a recommended useful diagnostic tool in chronic endometritis screening in asymptomatic infertile women.