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345873

Use of Fibrinogen in Prevention and Management of Postpartum Haemorrhage in High Risk Patient

Article

Last updated: 24 Dec 2024

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Abstract

Postpartum hemorrhage (PPH) remains a leading cause of maternal morbidity and mortality, particularly in high-risk pregnant patients. The early prediction and effective management of PPH are crucial to improving maternal outcomes. Serum fibrinogen levels have emerged as a potential biomarker for predicting and managing PPH. This study aimed to study the role of serum fibrinogen level in prediction and anticipation of postpartum hemorrhage and its role in the treatment. Methods: This cross-sectional observational study was carried out on pregnant females at high risk of PPH attending Benha University Hospital and Toukh Central Hospital over a six-month period. Detailed clinical assessments, laboratory investigations, and obstetric monitoring were conducted. Serum fibrinogen levels were measured using quantitative analysis. Antenatal and intrapartum care were tailored to patient needs. PPH cases received treatment with fibrinogen concentrate, cryoprecipitate, or fresh frozen plasma as indicated. Results: According to serum fibrinogen levels, the mean serum fibrinogen levels of the studied cases was 3.6 (±1.15) g/l. There was high statistically significant relation between bleeding severity and serum fibrinogen. According to Roc curve analysis for the use of serum fibrinogen levels to predict severity of bleeding, using serum fibrinogen levels at 3.95, it can predict PPH with 0.859 AUC, sensitivity 100%, specificity 71.9%, PPV 66.7%, NPV 100% and accuracy 82.0%. Conclusion: Serum fibrinogen levels show promise as a valuable predictor for PPH in high-risk pregnant patients. Monitoring fibrinogen levels could aid in early identification and timely intervention, potentially reducing the severity and complications of PPH.

DOI

10.21608/bmfj.2024.237805.1906

Keywords

Postpartum Hemorrhage, Serum Fibrinogen, high-risk pregnancy, predictive marker, Obstetric Management

Authors

First Name

Yehia

Last Name

Edris

MiddleName

Mohamed Samir

Affiliation

Department of Gynaecology & Obst- Facukty of Medicine- Benha University

Email

yehiaedris77@gmail.com

City

-

Orcid

-

First Name

Nabil

Last Name

Eldeen

MiddleName

Gamal

Affiliation

Professor of Obstetrics and Gynecology, Faculty of Medicine, Benha University.

Email

surgendo@yahoo.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Abd Elmoghney

MiddleName

Abd Elrahman

Affiliation

Department of Obstetrics and Gynecology Faculty of Medicine , Benha University

Email

mandrmahmoud22@gmail.com

City

-

Orcid

-

First Name

Waleed

Last Name

Tawfik

MiddleName

Mohammed

Affiliation

Gynecology and obstetrics department Faculty of medicine Benha university

Email

whsa251@gmail.com

City

-

Orcid

-

Volume

41

Article Issue

4

Related Issue

49714

Issue Date

2024-08-01

Receive Date

2023-09-20

Publish Date

2024-08-01

Page Start

126

Page End

135

Print ISSN

1110-208X

Online ISSN

2357-0016

Link

https://bmfj.journals.ekb.eg/article_345873.html

Detail API

https://bmfj.journals.ekb.eg/service?article_code=345873

Order

12

Type

Original Article

Type Code

787

Publication Type

Journal

Publication Title

Benha Medical Journal

Publication Link

https://bmfj.journals.ekb.eg/

MainTitle

Use of Fibrinogen in Prevention and Management of Postpartum Haemorrhage in High Risk Patient

Details

Type

Article

Created At

24 Dec 2024