patients with non alcoholic fatty liver disease (NAFLD) are commonly asymptomatic and identified incidentally. Liver biopsy is the gold standard for diagnosing nonalcoholic fatty liver. However this method is not only invasive and expensive but also has important limitations, including pain, patients reluctance and risk of severe complications. Additionally, the platelet count and platelet-related indices, such as the Age-platelet (AP) Index, AST to Platelet Ratio(APRI) Index, and Fibrosis-4 (FIB4) Index have been widely used to evaluate the severity of various liver diseases but less accurate. Aim of the work: To assess the red cell distribution width-to-platelet ratio as a predictor of liver fibrosis in patients with NAFLD. Material and methods: This prospective study was conducted on a selected group of 125 patients. All patients underwent a thorough history taking, comprehensive clinical examination, body mass index assessment and laboratory investigation including complete blood count (CBC), RDW to platelet ratio (RPR) calculated as RDW multiplied by 100 divided by platelet (109/L), ALT,AST, triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c). Additionally, imaging studies such as Pelvi_abdominal U/S and Fibroscan were performed. Results: Severe fibrosis was associated with diabetes, increased BMI, decreased platelet count, elevated RDW/PLT ratio and elevated ALT and AST. There was a positive correlation between RPR and increased age, obesity, increased RDW and AST and advanced fibrosis. However, there was a negative correlation with male gender, decreased platelet count and decreased TLC. Conclusion: RPR is a good predictor for liver fibrosis in NAFLD patients