Background: Endometrial carcinoma (EC) is the 6th most common cancer worldwide. SOX4 has been used as an immunohistochemical marker. Expression of SOX4 by cancer cells has been demonstrated in EC. Nuclear morphometry is an imaging technique that plays important roles in endometrial hyperplasia (EH) and EC. Aim: This work aims to evaluate SOX4 expression and nuclear morphometry in EH and EC and the relation between its expression and different clinicopathological variables. Material and method: This is a selected retrospective study including 60 different cases of EC and EH. SOX4 immunostaining and nuclear morphometry were performed for all cases. Results: There was a highly significant statistical difference between SOX4 expression in studied cases according to type, FIGO grade, depth of myometrial invasion, LVSI, T/B configuration, desmoplasia, mitotic count, T, N, M components, TNM and FIGO stage (P