Background: Diseases of the gallbladder are relatively common, and the most common pathology ischolelithiasis, affecting 10 – 15 % of the population. Aim and objectives: To study the detection rate of gallbladder diseases by Endoscopic Ultrasound (EUS) in comparison to Trans abdominal Ultrasound (TAUS). Patient and methods: This was a prospective cross sectional study conducted on 100 patients fulfilling the inclusion criteria in Maadi Military Hospital. All the data were collected from the patients from medical record of the hospital after ethical approval. Results: According to indication of EUS there were 19 (19%) patients had pancreatic mass, 55 (55%) patients had abdominal pain, 8 (8%) patients had pancreatitis, 12 (12%) patients had obstructive jaundice, 4 (4%) patients had pancreatic cyst, and 2 (2%) patients had a follow up cancer. Our results showed that there was a significant relationship between EUS and trans abdominal US findings (P value