ABSTRACT


Osteoarthritis (OA) is a degenerative joint disease, it is additionally referred to the most common type of arthritis. OA is graded collectively as one of the leading causes of disability among the elders.
An ideal therapy ought to deal with both inflammatory and tissue degeneration processes in the joint building tissue. Regenerative medicine is an exciting potential non-invasive therapeutic alternative to total joint replacement for treating osteoarthritis. Encouraging results of pre-clinical and clinical trials that provided initial proof of efficacy and safety in the therapeutic impact of using mesenchymal stem cell therapies for the treatment of knee osteoarthritis.

This review study aimed to discuss the safety and efficacy of autologous mesenchymal stem cells (MSCs) intra-articular injection in treating patients with knee OA classified grade II and III according to Kellgren and Lawrence system.
Assessment of potential therapeutic effect of autuologus bone marrow derived mesenchymal stem cells transplantations in patients with grade II/III osteoarthritis.

This review concluded that, Mesenchymal stem cells (MSCs) are the most used for therapeutic cause and cartilage regeneration, and their safety and effectiveness have been demonstrated in basic research and clinical studies. There are many clinical experiments of stem cells showing a satisfactory healing effect in cartilage damage repair, but further studies are still required to test the effectiveness and safety of stem cells for cartilage repair.