Background: Retinal vein occlusion (RVO) is the second most common retinal vascular disease following diabetic retinopathy and is a frequent cause of significant visual loss and associated morbidity. Aim and objectives: To assess peripapillary vessel density (VD) , retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in the fellow eyes of patients with unilateral retinal vein occlusion (Rvo) (either CRVO or BRVO) using optical coherence tomography angiography (OCTA) and compare it with controls. Subjects and methods: This is an observational study that will be conducted on (25) patients with unilateral RVO (either CRVO or BRVO) and (25) normal controls chosen from outpatient clinic. Results: The RNFL thickness in the fellow eyes of RVO patients was significantly thinner than in normal controls .There was no significant difference between fellow eyes and healthy controls as regard to VD of peripapillary plexus and ganglion cell complex thickness Conclusion: OCTA revealed that RNFL thickness in the fellow eyes of patients with unilateral RVO was significantly decreased. Peripapillary VD and GCC thickness showed no significant difference when compared to healthy controls.