Background: Optical Coherence Tomography Angiography (OCTA) is a new, non-invasive imaging technique that generates angiography images in a matter of seconds and can detect posterior segment complications of high myopia. Objectives: Assessment of peripapillary changes in high myopia and to quantify vasculature parameters using Optical Coherence Tomography Angiography (OCTA) to determine the relation between retinal vasculature and peripapillary parameters in highly myopic eyes. Methods: This study is an observational cross- sectional study for high myopic patients, Study will include 130 eyes of 70 patients included 2 groups;group (A) of high myopic (N=100 eyes of 55 patients), group (B) (N=30 healthy eyes of 15 populations) of emmetropia. All patients were subjected to full ophthalmologic evaluation, AL measurement, OCTA and Fundus photo. Results: The results of the study revealed a statistically significant difference in the RNFL thickness (average, superior, inferior and nasal) (p value