Background: Reducing IOP has been repeatedly shown to be an effective intervention across the glaucoma spectrum, regardless of subtype & disease stage. This study aimed to compare optic disc perfusion & radial peri-papillary capillary plexus density between the control group & primary open-angle glaucomatous patients using Ocular Coherence Tomography Angiography. Methods: This research was carried out at the outpatient clinic of the Ophthalmology Department of Banha University Hospitals on 25 studied cases suffering from glaucoma (Group A). 25 healthy individuals of matched years old & gender were chosen as the control group (Group B) Scanned with OCT-A for optic disc perfusion and radial peri-papillary capillary plexus density and Superficial macular capillary plexuses density. Results: There was a highly statistically significant variation among 2 studied groups as regards the whole image density of the optic disc in which the mean inpatient group was (32,81) but in the control was (49.74) with P (