Background: Increase prevalence of obesity is linked with increase the threat of various diseases such as cardiovascular disease, diabetes, cancer, and many gastrointestinal complications of obesity.
Objective: Study the relationship between obesity, endoscopic gastritis, and serum Adiponectin level in obese persons.
Methods: This study was done on sixty-five patients diagnosed with chronic gastritis by upper endoscopy according to Sydney system, categorized into three groups according to their BMI, group A: BMI less than 25, group B: BMI from 25 to 30 and group C: BMI more than 30. Careful clinical examination, CBC, lipid profile, H. pylori antigen in the stool and serum Adiponectin by ELISA technique were done.
Results: BMI showed statistically significant difference between all studied groups. 49.2% of our study patients had erosive gastritis, 29.9% had hemorrhagic gastritis and 21.5% had atrophic gastritis. Serum Adiponectin showed statistically significant difference between all studied groups. According to Roc curve of serum Adiponectin, a cutoff level lower than 7 microgram/ml is diagnostic of endoscopic gastritis in obese persons with AUC about 0.841, sensitivity of 86%, specificity of 73%, negative predictive value of 81%, positive predictive value of 79% and accuracy of 80%. Lower Adiponectin level was found in erosive gastritis compared to hemorrhagic and atrophic gastritis. Erosive gastritis had the highest BMI followed by hemorrhagic and the least was atrophic gastritis group.
Conclusion: Obese subjects have a lower serum Adiponectin level which may be a risk factor of incidence of gastritis and its types.