Background : Prostate cancer is one of the most frequent malignancy worldwide . Mucin 4(MUC4) is a transmembrane mucin that is contributed in cell signalling events that guide the proliferation of cells. Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been linked to tumorgenesis and progression of many cancers.
Aim: This study aimed to evaluate MUC4 and IMP-3 expression in different prostatic lesions and to relate the results with clinicopathological data.
Material & method:
This retrospective study examined 40 cases including10 cases of benign prostatic hyperplasia (BPH), 6 cases of high-grade prostatic intraepithelial neoplasia (HGPIN) and 24 cases of prostatic adenocarcinoma (PCa) . MUC 4 and IMP-3 were used for the immunohistochemistry.
Results: MUC4 was detected in (100%) of BPH & HGPIN cases and (16.6%) of prostatic carcinoma.IMP3 expressed in (100%) of prostatic cancer cases and expressed in(10%) &(16.7%) of &HGPIN respectively. A significant statistical correlations between IMP3expression and stage, Gleason's grade ,pre OP serum PSA level>10ng/ml, capsular and perineural invasion(P