Background: Non-alcoholic fatty liver disease or more recently re-defined metabolic associated fatty liver disease (MAFLD) is regarded as the most relevant liver disease of the twenty-first century, affecting at least one third of the general population. This study aimed to study the association between serum uric acid (SUA) and MAFLD in obese and lean patients. Methods: This cross-sectional study was conducted on lean MAFLD patients compared with obese MAFLD patients who attended inpatient and outpatient clinics of Hepatology and Gastroenterology department of Benha University Hospital. Patients were divided into 2 equal groups: Group I: included 45 lean MAFLD patients and Group II: included 45 obese MAFLD patients. Results: Serum creatinine was significantly lower in group I compared to group II (P value =0.001). There was a significant positive correlation between CAP score and Albumin (r=0.222, P=0.036), cholesterol (r=0.333, P=0.001) and serum uric acid (r=0.289, P=0.006). There was a significant positive correlation between serum uric acid and cholesterol (r=0.300, P=0.004), LDL (r=0.301, P=0.00) and CAP score (r=0.289, P=0.006). Conclusion: Our study supports the rationale for serum uric acid (SUA) being established as another risk factor for metabolic dysfunctions in lean/normal-weight and obese MAFLD.