Abstract
Background: Acne vulgaris is characterized either by non inflammatory, open or closed comedones and by inflammatory papules, pustules, and nodules. Local symptoms of acne vulgaris may include pain, tenderness, or erythema. Cathepsin S is unique amongst the cysteine cathepsin family due to restricted tissue expression, associated with antigen presenting cells localized in lymph and spleen, as well as other immune cells such as macrophages. The aim was to assess serum Cathepsin S level in patients with active acne vulgaris. Methods: This case control study was conducted on 25 patients suffering from active acne vulgaris and 25 control group. All patients were subjected to the following: A complete history Dermatological clinical examination was done. Estimation of serum levels of Cathepsin S were measured. Results: No significant correlations were found between CTS and other numerical variables. CTSS showed significantly higher levels in Acne vulgaris group when compared to control group. There was no statistically significant difference between Acne Grading regarding CTS. There was no statistically significant difference between Scar grade regarding CTS. Conclusion: CTSS was higher in Acne vulgaris group compared to control group. No statistically significant association was found between Cathepsin S level and patients with active Acne Vulgaris.