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284008

Progranulin Versus Procalcitonin as a Novel Biomarker in Diagnosis of Early-Onset Neonatal Sepsis

Article

Last updated: 24 Dec 2024

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Abstract

Background: Neonatal sepsis is the third most common reason for neonatal mortality, which is a serious health issue. Early diagnosis can help these neonates have better outcomes. Objective: Progranulin (PGRN) and procalcitonin (PCT) were evaluated for their diagnostic utility in early-onset sepsis (EOS). Methods: The neonates in this study were born at ≥ 34 weeks gestation and hospitalized to the Neonatal Intensive Care Unit within the first 72 hours of life. The infected group contained 50 infants, whereas the uninfected group included 60 neonates. All infants had thorough clinical evaluations and lab testing. The levels of procalcitonin and progranulin in the serum were determined using ELISA. Results: At the three-time intervals, there was no noticeable difference between the groups in terms of CRP. With a p-value of 0.003, PCT was statistically more significant in the infected group (0.990.50 ng/dl) than in the uninfected group (0.40.44 ng/dl) during the 1-24 h interval, but there was no difference at the 24-48 h or 49-72 h intervals. At each of the three-time intervals when the infected and uninfected groups were compared, PGRN was considerably higher in the infected group (p 0.001). Furthermore, PGRN was statistically greater during 49-72 h intervals in the infected group compared to 1-24 h and 25-48 breaks (p=0.004). However, at various intervals, the PGRN levels in the uninfected group did not vary significantly (p=0.053). Conclusion: PGRN was found in newborn sepsis with an early onset and may be helpful as a biomarker for diagnosis.

DOI

10.21608/bmfj.2023.171497.1698

Keywords

Progranulin, Procalcitonin, biomarker, Neonatal, Sepsis

Authors

First Name

Eman

Last Name

Abd Almonaem

MiddleName

Rateb

Affiliation

Department of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt.

Email

emanrateb79@gmail.com

City

-

Orcid

-

First Name

Osama

Last Name

Elfiky

MiddleName

Abu El fotoh

Affiliation

Department of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt.

Email

osamafotoh00@gmail.com

City

-

Orcid

-

First Name

Seham

Last Name

Ameen

MiddleName

Gouda

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt.

Email

seham.ameen@fmed.bu.edu.eg.com

City

-

Orcid

-

First Name

Alaa

Last Name

Elsharnoby

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt.

Email

alaaashafy2017@gmail.com

City

Baltim

Orcid

-

Volume

40

Article Issue

2

Related Issue

43348

Issue Date

2023-09-01

Receive Date

2022-10-30

Publish Date

2023-09-01

Page Start

379

Page End

388

Print ISSN

1110-208X

Online ISSN

2357-0016

Link

https://bmfj.journals.ekb.eg/article_284008.html

Detail API

https://bmfj.journals.ekb.eg/service?article_code=284008

Order

6

Type

Original Article

Type Code

787

Publication Type

Journal

Publication Title

Benha Medical Journal

Publication Link

https://bmfj.journals.ekb.eg/

MainTitle

Progranulin Versus Procalcitonin as a Novel Biomarker in Diagnosis of Early-Onset Neonatal Sepsis

Details

Type

Article

Created At

24 Dec 2024