Background: Detection of breast recurrence malignancies in cases previously treated for breast cancer with either breast conserving surgery or with radical mastectomy is much more difficult than diagnosis of the primary tumor. Multiparametric magnetic resonant imaging of the breast aims to simultaneously quantify and visualize multiple functional processes at the cellular and molecular levels.
Purpose: To assess the diagnostic value of multiparametric magnetic resonant imaging in assessment of post-operative breast masses and differentiating recurrent malignancy from other post-operative lesions.
Patient and methods: this prospective study carried on thirty female patients who underwent breast conserving surgery or radical mastectomy. Patients were examined by sono-mammography that aroused suspicious of breast lesions followed by DCE-MRI & DWI-MRI with or without MRS to exclude recurrence. Multiparametric MRI with 2 (DCE MRI and DWI) or 3 (DCE MRI, DWI, and MRS) parameters was done at 1.5- T MR Machine. Histopathology or short term imaging follow up was used as the gold standard.
Results: MP MRI showed no false negatives and there was a significant reduction in false-positive lesions (only two) compared with DCE MRI with 100% sensitivity, 88.9%specificity, 85.7 % PPV, 100 % NPV and 93.3 % accuracy, MP MRI allows an increase in both sensitivity and particularly specificity, resulting in a significantly improved diagnostic accuracy
Conclusion: MP MRI has a great diagnostic accuracy for post-operative detection of recurrent breast cancer.