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275475

Does Latent Toxoplasmosis Impacts SARS-CoV-2 Infection Severity and Outcome?: A Cross-Sectional Study in Benha, Egypt.

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Last updated: 24 Dec 2024

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Abstract

Background: The unique single-stranded RNA virus COVID-19 is to blame for the initial viral pneumonia outbreak in China that quickly turned into a pandemic. The "immune exhaustion" which flares up viral multiplication and hasty clinical results, is one of the primary criteria of the immune response against COVID-19 and also, it is a common side effect of chronic infections with Toxoplasma gondii. The severity of COVID-19 could possibly be increased by the toxoplasmosis-associated immune depletion by making it worse.
Aim of study: Our goal was to ascertain the prevalence of coinfection with latent toxoplasmosis in COVID 19 positive patients as well as its impact on the progression of the infection and the fate of the disease.
Patients &Methods: 50 patients with PCR-comfirmed COVID-19 infection were recruited for this cross sectional cohort prospective study at benha university hospitals. They underwent Toxoplasma IgG testing by ELISA and had their conditions monitored to assess the COVID-19 infection's outcome.
Results: Toxoplasma IgG seropositivity was found in 29(58%) patients while history of animal contact was 48.3% and 38.1% in both IgG positive and negative groups respectively. Toxoplasma Positive group showed higher incidence of: long hospital stay (20.7±7.3), ICU admission (72.4%), need for ventilation (55.3%), more lung affection and sever CT findings (24.1%) and higher death rate (10.3%). All these previous differences were statistically significant.
Conclusion: The concurrent latent toxoplasmosis infection in (SARS-CoV-2) patients was linked to a more severe course and a worse result of COVID-19 infection.

DOI

10.21608/bmfj.2022.174306.1705

Keywords

Keywords: COVID‐19, parasitic infections, Toxoplasmosis

Authors

First Name

asmaa

Last Name

elkholy

MiddleName

A

Affiliation

parasitology department ,banha faculty of medicine ,banha university, banha ,egypt

Email

asmaakholy787@gmail.com

City

banha

Orcid

-

First Name

ghada

Last Name

omar

MiddleName

helmy

Affiliation

parasitology department ,banha faculty of medicine ,banha university, banha ,egypt

Email

ghada234@yahoo.com

City

banha

Orcid

-

First Name

ayman

Last Name

elbadawy

MiddleName

mohamed

Affiliation

internal medicine department ,banha faculty of medicine ,banha university, banha ,egypt

Email

aymanelbadawy74@gmail.com

City

banha

Orcid

-

First Name

rasha

Last Name

omar

MiddleName

A

Affiliation

internal medicine department ,banha faculty of medicine ,banha university, banha ,egypt

Email

rashaomar@gmail.com

City

banha

Orcid

-

First Name

amira

Last Name

mohamady

MiddleName

A

Affiliation

internal medicine department ,banha faculty of medicine ,banha university, banha ,egypt

Email

amiramohamady@yahoo.com

City

banha

Orcid

-

First Name

rabab

Last Name

omar

MiddleName

ELSAYED

Affiliation

parasitology department ,banha faculty of medicine ,banha university, banha ,egypt

Email

dr_rabab88@yanoo.com

City

banha

Orcid

-

First Name

amira

Last Name

ramadan

MiddleName

essam

Affiliation

microbiology department ,banha faculty of medicine ,banha university, banha ,egypt

Email

amiraessam@yahoo.com

City

banha

Orcid

-

First Name

Eman

Last Name

Araby

MiddleName

Mohammed

Affiliation

assistant professor of Public health& community medicine , Benha faculty of medicine, Benha university, Benha city, Qualubia Governorate, Egypt.

Email

dremanaraby77@gmail.com

City

Benha

Orcid

0000-0001-6122-9173

First Name

seham

Last Name

ameen

MiddleName

gouda

Affiliation

Clinical and Chemical Pathology Faculty of Medicine, Benha University.

Email

seham.ameen@fmed.bu.edu.eg

City

banha

Orcid

0000-0002-1988-0082

First Name

ahmed

Last Name

mansour

MiddleName

ezzat

Affiliation

internal medicine department ,banha faculty of medicine ,banha university, banha ,egypt

Email

drahmed77@yahoo.com

City

banha

Orcid

-

Volume

40

Article Issue

1

Related Issue

41306

Issue Date

2023-05-01

Receive Date

2022-11-14

Publish Date

2023-05-01

Page Start

80

Page End

96

Print ISSN

1110-208X

Online ISSN

2357-0016

Article File

BMFJ_Volume 40_Issue 1_Pages 80-96.pdf

PDF . 918.2kB

Link

https://bmfj.journals.ekb.eg/article_275475.html

Detail API

https://bmfj.journals.ekb.eg/service?article_code=275475

Order

8

Type

Original Article

Type Code

787

Publication Type

Journal

Publication Title

Benha Medical Journal

Publication Link

https://bmfj.journals.ekb.eg/

MainTitle

Does Latent Toxoplasmosis Impacts SARS-CoV-2 Infection Severity and Outcome?: A Cross-Sectional Study in Benha, Egypt.

Details

Type

Article

Created At

24 Dec 2024