Background: Maternal iron condition influences the iron status of neonates since iron transferred from the mother is the only source for fetal iron. The aim of this study was to examine the association of obesity with inflammatory markers (CRP) and iron status in both mother and infant. Methods: This comparative cross sectional study was conducted on 100 pregnant women and their neonate from the attendance of Agouza police Hospital and Benha University Hospitals. Results: Our results shows that there was no statistically significant difference found between obese and non obese pregnant women regarding neonatal HB, TLC, Platelet , Serum iron in cord, TIBC in cord and CRP in cord. There was a negative impact of maternal BMI on neonatal iron status. The maternal obesity was inversely associated with cord ferritin concentrations, poorer iron status determined by cord ferritin were evident in the neonates of obese women, compared with those born to normal weight women. Maternal CRP ,maternal hepcidin and maternal serum transferrin receptor were greater in obese compared with normal weight pregnant women. Conclusion: There is a negative impact of maternal BMI on neonatal iron status. The maternal obesity was inversely associated with cord ferritin concentrations, poorer iron status determined by cord ferritin were evident in the neonates of obese women, compared with those born to normal weight women. The concentrations of CRP was greater in obese compared with normal weight pregnant women. Serum hepcidin was elevated in obese pregnant women compared with the normal weight women in this study.