Aim: This study aims to investigate the relationship of several parameters of complete blood count (CBC) including RDW with N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in a cohort of acute myocardial infarction (AMI) patients.

Methods: A total of 45 participants (30 patients diagnosed with AMI and 15 healthy individuals) at Sohag Cardiology and Gastroenterology Center, Department of Cardiology and CCU from 1st March to 30th September 2023. were screened for enrollment in this prospective study. All agreed to participate in this prospective study, they all were subjected to routine investigation (CBC including RDW) and specific investigations (NT-proBNP and cTnT).

Results: This case-control study was conducted among 45 participants then they were divided into 2 main groups: 1st case group (30 patients diagnosed with AMI ) and 2nd control group(15 healthy individuals not known to have AMI), To find that there is a positive relationship between Red Cell Distribution Width, NT-proBNP and cTnT in Acute Myocardial Infarction Patients.

Conclusion: High levels of RDW were associated with AMI at admission and RDW is a widely available marker with no additional costs, in contrast to other novel markers of cardiovascular risk. A high RDW may be associated with the severity and instability of acute myocardial infarction.The combined use of presentation values of cTnT and its absolute change in the following hours has a significantly higher diagnostic accuracy for AMI than relative changes and seems therefore to be the preferred criteria to distinguish AMI from other causes of cTn elevations.