Human schistosomiasis is considered one of the most important parasitic diseases, endemic in 78 countries, including tropical and subtropical regions and infecting about 250 million individuals worldwide. Recently the treatment of schistosomiasis depends mainly on the anti-parasitic drug, praziquantel; which was found to be not fully effective and its excessive usage resulted in the development of resistant strains of Schistosoma mansonai. Nowadays, therapeutic potential of natural products and medicinal plants which frequently are considered to be less toxic and free of side effects in treating certain diseases, is widely recognized. According to a prophetic hadith, Muslims believe that Nigella sativa is the remedy for all diseases except death. Its essential oil is considered one of the promising alternative drugs for the treatment of Schistosma mansonai with potent antischistosomal effects. Nanoparticles can be used as drug carriers to modulate pharmacokinetics, boost bioavailability and target release with limited harmful effects. Nigella sativa can be incorporated into nanoparticles and is considered as a new delivery system and a suitable carrier with high physical stability. Different studies showed that it can be used as efficient drug delivery vehicle in treating Schistosoma mansonai. This article aims to highlight the therapeutic effect of Nigella sativa loaded nanoparticles on murine schistosomiasis mansonai.