Impact Of Type 2 Diabetes Mellitus On Activated Partial Thromboplastin Time and Serum Fibrinogen In Non-dialysis Chronic Kidney Disease Patients



ABSTRACT

Background: due to abnormalities in coagulation and hypo-fibrinolysis, diabetes mellitus is linked to an increased risk of thrombotic complications. In patients with chronic kidney disease (CKD), pro- and anti-hemostatic factors are disrupted, leading to both bleeding and thrombotic complications. However, few studies have shown how diabetes mellitus affects serum fibrinogen levels and APTT in non-dialysis CKD patients.

Aim of the work: To investigate impact of type 2 DM on APTT and serum fibrinogen in Non-dialysis CKD patients.

Patients and methods: 150 patients classified into 3 groups each group included 50 patients, group with DM only patients, group with CKD only patients and group with CKD and DM patients , demographic data, APTT, serum fibrinogen , HbA1c and eGFR were done for all patients.

Results: Combining DM with CKD led to a significant increase in serum fibrinogen level (p<0.0001) and a reduction in APTT (p<0.0001). Serum fibrinogen also showed a positive correlation with HbA1c and eGFR (p<0.0001, r = 0.8 ) (P <0.002, r = 0.26) and a negative correlation (P<0.0001, r = -0.66 ) ( P< 0.0001, r = -0.50) with HbA1c and eGFR.

Conclusion: Serum fibrinogen, APTT, and glycemic state should all be closely watched in non-dialysis CKD patients, This can help lower the risk of thrombosis in the future.

Keywords: Type 2 diabetes mellitus; APTT; Fibrinogen ; Non-dialysis chronic kidney disease .