Background: The current gold standard for treating breast cancer is a combination of radiation and breast oncoplastic treatments. Malignancies in the top quadrants of big, ptotic breasts, inferior pedicle mammoplasty allows for quadrantectomies to be conducted without changing the breast's shape of breast . Aesthetically attractive with substantial safety margins is the goal of therapeutic mammoplasty.

The aim of study: To treat early-stage breast cancer in women with big breasts using the inferior pedicle therapeutic mammoplasty technique. Methods: This research comprised fifteen large-breasted women who were diagnosed with breast cancer during the months of June 2019 and June 2021. Results: The patients' ages varied from 31 to 57 years (median 49.7), and the tumor sizes ranged from one to three and a half centimeters. The weight of the excised tissue ranged from 350 grams to 780 grams. A patient had a straightforward mastectomy because to the presence of infiltrative margin measuring 7.14%. The most frequent consequences after surgery are inflammation and wound infection, affecting two patients (14.28%). In one instance (7.14%), cancer recurred and required local incision. Out of the total number of patients, 10 individuals (71.4%) had an exceptional cosmetic outcome. One patient (7.1%) had good results, while two patients (14.3%) reported passable outcomes. Unfortunately, one patient (7.1%) experienced a negative result. The duration of the follow-up ranges from 6 to 42 months.

Conclusion: The inferior pedicle therapeutic mammoplasty is effective surgical treatment for early breast cancer in women with big breasts , also provides a pleasing cosmetic result.